Many people just don’t know what to say and will respond to any attempt to start a conversation. It’s worth a try.
Here’s a neat trick: Start by asking the question you want the other person to ask you. What’s the most interesting thing you do or know or like. Because, usually, the polite thing to say after answering a question is “How about you?”
When I was working as a typist or secretary or personal assistant, I never asked people “What do you do?”